Namzaric Capsule: Uses, Dosage, Side Effects, Precautions and Alternates

Quick overview

Namzaric Capsule combines memantine hydrochloride and donepezil hydrochloride, an NMDA receptor antagonist and acetylcholinesterase inhibitor. It is a prescription medicine used to treat moderate to severe dementia caused by Alzheimer's disease in patients already stabilized on memantine and donepezil hydrochloride 10 mg. It is not known to be safe and effective in children, and it does not cure Alzheimer's disease.

What is Namzaric Capsule

Namzaric is a prescription medicine that combines two drugs, memantine and donepezil, used to treat moderate to severe dementia caused by Alzheimer's disease. It is not known if it is safe and effective in children, and it does not cure Alzheimer's disease.

Namzaric Capsule uses

• Treatment of moderate to severe dementia of the Alzheimer's type in patients already stabilized on memantine and donepezil hydrochloride 10 mg

Benefits of Namzaric Capsule

• Helps manage moderate to severe Alzheimer's disease.
• May improve memory-related symptoms.
• Supports thinking and attention.
• May help with daily activities.
• May help slow worsening of symptoms.

How Namzaric Capsule works

Namzaric contains two medicines. Memantine blocks the effects of a brain chemical called glutamate that is linked to Alzheimer's symptoms. Donepezil prevents the breakdown of a brain chemical called acetylcholine, allowing more of it to build up in the brain, which helps with memory and thinking.

Namzaric Capsule dosage

Take Namzaric by mouth one time each evening before going to bed, unless your doctor tells you otherwise. Take with or without food. Swallow the capsule whole; do not divide, chew, or crush it. If you cannot swallow it whole, the capsule may be opened and the entire contents sprinkled on a spoonful of applesauce, then swallowed right away without chewing; do not save the mixture for later use. Do not use a capsule that is broken, damaged, or shows signs of tampering.

If you miss a dose, take it at your next scheduled time; do not take two doses at the same time or double up. Do not stop taking Namzaric suddenly without talking to your doctor, as this may make your condition worse. Tell your surgeon or dentist ahead of time if you are using Namzaric, since you may need to stop it for a short time before a procedure.

Available forms and strengths

• Capsule

Side effects of Namzaric Capsule

Common

• Headache
• Dizziness
• Diarrhea
• Nausea or vomiting
• Loss of appetite
• Bruising (ecchymosis)
• Constipation
• Weight gain
• Back pain
• Sleepiness
• Depression
• Blood pressure changes
• Nervousness
• Hallucinations
• Trouble sleeping (insomnia)
• Aggressive behavior
• Eczema

Serious

• Severe allergic reaction (breathing problems, swelling of face/lips/mouth/tongue/throat, hives, trouble swallowing)
• Heart rhythm changes, slow heartbeat, or fainting
• Stomach bleeding or ulcers (vomiting blood, black or tarry stools, severe stomach pain)
• Inability to empty the bladder or difficulty passing urine
• Seizures
• Worsening of lung problems in people with asthma or other lung disease

Warnings and precautions

• Namzaric may worsen the effects of certain muscle relaxants used during anesthesia, so tell your surgeon or dentist you are taking it before any procedure.
• Namzaric can affect heart rhythm and may cause a slow heartbeat or heart block, which can lead to fainting.
• Namzaric may increase the risk of stomach or intestinal ulcers and bleeding, especially in people with a history of ulcers or who take NSAIDs.
• Namzaric commonly causes diarrhea, nausea, and vomiting, especially when starting treatment.
• Namzaric may cause difficulty emptying the bladder.
• People with asthma or other lung conditions should use Namzaric with care, as it may worsen these conditions.
• Namzaric is contraindicated in people who are allergic to memantine, donepezil, piperidine-related medicines, or any of its ingredients.
• It is not known if or how Namzaric could affect pregnancy or harm an unborn baby. Tell your doctor if you are or plan to become pregnant.
• It is not known if Namzaric passes into breast milk. Talk to your doctor about the best way to feed your baby if you take Namzaric.
• Tell your doctor if you have kidney problems. A lower dose may be needed for people with severe kidney impairment.
• Tell your doctor if you have liver problems. Namzaric has not been studied in people with severe liver impairment.
• It is not known for certain if alcohol affects Namzaric, but drinking alcohol while taking it may increase the risk of dizziness.

Storage

• Store at room temperature, between 68°F to 77°F (20°C to 25°C)
• Can be exposed to temperatures between 59°F to 86°F (15°C to 30°C) for shorter periods, such as during transport
• Store in a cool, dry place away from moisture, heat, and light
• Keep capsules in the original prescription container or other light-resistant container

When to see a doctor

• Get emergency help right away if you have signs of a severe allergic reaction, such as breathing problems, swelling of the face, lips, mouth, tongue, or throat, or hives.
• Stop taking Namzaric and call your doctor right away if you have chest pain, a slow heartbeat, or feel like you might faint.
• Stop taking Namzaric and get emergency help if you have signs of stomach bleeding, such as vomiting blood, black or tarry stools, or vomit that looks like coffee grounds.
• Call your doctor right away if you cannot empty your bladder or have painful or difficult urination.
• Stop taking Namzaric and call your doctor if you have signs of a seizure, such as muscle twitching, jerking, stiffening, confusion, or loss of consciousness.
• If you think you or someone else has taken too much Namzaric, get medical help right away or contact a poison control center.

Alternatives

• Rivastigmine
• Memantine
• Donepezil