Rocklatan Eye Drops: Uses, Dosage, Side Effects, Precautions and Alternates

Quick overview

Rocklatan Eye Drops combine latanoprost and netarsudil in one ophthalmic solution used to lower high pressure inside the eye in adults. It is prescribed for increased eye pressure caused by ocular hypertension or open-angle glaucoma. Rocklatan is used once daily in the evening and is meant for long-term use as directed by a doctor.

What is Rocklatan Eye Drops

Rocklatan is a brand-name prescription eye drop that combines two medicines, netarsudil and latanoprost, in one liquid solution. It belongs to the ophthalmic glaucoma agents class, specifically a Rho kinase inhibitor combined with a prostaglandin analog. It's used to lower high pressure inside the eye in adults.

Rocklatan Eye Drops uses

• Treats increased eye pressure caused by ocular hypertension (high pressure in the eye from fluid buildup)
• Treats increased eye pressure caused by open-angle glaucoma, the most common type of glaucoma

Benefits of Rocklatan Eye Drops

• Lowers eye pressure more than either of its two ingredients used alone
• Combines two medicines into one once-daily eye drop for convenience
• Begins lowering eye pressure after the first dose

How Rocklatan Eye Drops works

Rocklatan contains two medicines, netarsudil and latanoprost, that both work by helping fluid drain out of the eye more easily. This reduces the buildup of fluid (called aqueous humor) that causes increased eye pressure.

Rocklatan Eye Drops dosage

Use one drop in the affected eye or eyes once a day, in the evening. Wash your hands before using the eye drops. Don't let the dropper tip touch your eye, fingers, or any other surface, to avoid contaminating the solution.

If you wear soft contact lenses, take them out before using the drops; you can put them back in 15 minutes after using the drops. Tilt your head back, pull down your lower eyelid to make a small pocket, and place one drop into the pocket, then close your eyes for a minute or two.

If you use other eye drops or ointments, wait at least 5 minutes between each one so your eye can absorb each medicine. This medicine is meant to be used long term, for as long as your doctor prescribes it. It is not approved for use in anyone younger than 18 years old.

Available forms and strengths

• Ophthalmic solution (eye drop liquid) in a multi-use dropper bottle

Side effects of Rocklatan Eye Drops

Common

• Eye redness
• Eye pain after using the drops
• Deposits on the surface of the eye (corneal verticillata)
• Bleeding in the white part of the eye (conjunctival hemorrhage)
• Itchy eye
• Watery eye
• Eye discomfort
• Dry eyes
• Blurry vision

Serious

• Seeing less clearly, with symptoms like blurry vision, trouble reading, or headaches
• Macular edema (fluid buildup in part of the eye) that can cause blurry vision, changes in how you see color, or vision loss
• Changes in eye color, especially the iris becoming more brown, which may be permanent
• Eyelash changes, such as lashes becoming thicker, longer, or more numerous, usually reversible
• Allergic reaction, including hives, trouble breathing, or swelling of the face, lips, tongue, or throat
• Eye swelling, redness, severe discomfort, crusting, or drainage, which may be signs of infection
• Severe burning, stinging, or irritation after using the drops

Warnings and precautions

• Don't use Rocklatan if you have swelling or inflammation in your eye, since one of its ingredients can make this worse.
• Avoid using Rocklatan if you currently have a herpes infection in the eye, as it may make the infection worse.
• If you don't have a natural lens in your eye, have a torn lens, or have an artificial lens, your doctor may need to watch you more closely, because these conditions raise the risk of swelling in the back of the eye.
• Rocklatan can cause a permanent increase in brown coloring in your iris, and it may darken your eyelids or eyelashes.
• Using a contaminated eye drop bottle can cause a serious eye infection. Never let the dropper tip touch your eye, fingers, or any surface.
• Don't use Rocklatan while wearing soft contact lenses, since a preservative in the drops can damage the lenses.
• Don't use other prostaglandin eye drops at the same time as Rocklatan, since this may make it less effective or raise your eye pressure instead.
• If you use other eye drops that contain a preservative called thimerosal, keep them at least 5 minutes apart from Rocklatan, since mixing them can cause a solid mass to form in the eye.
• It isn't known if Rocklatan is safe to use during pregnancy since it hasn't been well studied in pregnant people. It should only be used during pregnancy if the benefits outweigh the potential risks to the baby.
• It isn't known if Rocklatan is safe to use while breastfeeding or whether it passes into breast milk. Talk with your doctor about the risks and benefits if you are breastfeeding.
• Use cautiously if you have corneal disease, especially pre-existing corneal swelling or problems affecting the corneal endothelium. Contact your eye doctor if you develop eye pain or decreased vision, as Rocklatan can rarely cause epithelial corneal edema.
• Rocklatan may cause permanent darkening of the iris (eye color) and darkening of the eyelid skin. It may cause increased length, thickness, pigmentation, or number of eyelashes; these changes are usually reversible after stopping treatment. Use cautiously if you have a history of iritis or uveitis; avoid use during active intraocular inflammation. Use cautiously if you have risk factors for macular edema, including certain patients who are aphakic or have a damaged posterior lens capsule.
• There are no known interactions between Rocklatan and alcohol, but ask your doctor if it's safe for you to drink while using this medicine.
• Your vision may be blurry right after using the drops, so wait a few minutes for your vision to clear before driving or using machinery.

Storage

• Store in the refrigerator until the bottle is opened
• Keep at a temperature of 36°F to 46°F (2°C to 8°C) before opening
• Once opened, can be kept at 36°F to 77°F (2°C to 25°C) for up to 6 weeks
• If kept refrigerated after opening, the drops can be used until the expiration date on the bottle
• Protect from light
• Do not freeze
• Keep the bottle tightly closed when not in use
• Keep out of the reach of children and pets
• Dispose of unused medication safely; ask your pharmacist how to dispose of it properly

When to see a doctor

• Get emergency help right away if you have signs of a severe allergic reaction, such as hives, trouble breathing, or swelling of your face, lips, tongue, or throat.
• Stop using the drops and call your doctor right away if you notice eye swelling, redness, severe discomfort, crusting, drainage, red or swollen eyelids, vision changes, or severe burning, stinging, or irritation.
• Tell your doctor right away if you have an eye injury or eye infection, or if you're planning to have eye surgery.
• Contact your doctor right away if you notice any changes in your vision, such as blurriness or dull colors, since this could be a sign of swelling in the back of the eye.
• If you think you've used too much Rocklatan, contact your doctor or a poison control center for guidance, or seek emergency care if symptoms feel severe.

Alternatives

• latanoprost (Xalatan)
• netarsudil (Rhopressa)
• bimatoprost (Lumigan)
• brimonidine (Alphagan-P)
• latanoprostene bunod (Vyzulta)
• brinzolamide (Azopt)
• dorzolamide (Trusopt)
• dorzolamide/timolol (Cosopt)
• brimonidine/timolol (Combigan)
• timolol (Timoptic, Timoptic in Ocudose, Timoptic-XE)
• travoprost (Travatan-Z)
• betaxolol (Betoptic)
• carteolol