Ryaltris Nasal Spray: Uses, Dosage, Side Effects, Precautions and Alternates

Quick overview

Ryaltris Nasal Spray combines olopatadine hydrochloride, an antihistamine, with mometasone furoate monohydrate, a corticosteroid. It is a prescription nasal spray used to treat symptoms of moderate to severe seasonal allergic rhinitis (hay fever) and related eye symptoms in people 6 years of age and older. It works by blocking histamine and reducing inflammation in the nose, and is typically used twice daily.

What is Ryaltris Nasal Spray

RYALTRIS is a prescription nasal spray combining two medicines: olopatadine hydrochloride (an antihistamine) and mometasone furoate (a corticosteroid). It is used to treat symptoms of seasonal allergies and related eye symptoms in people 6 years of age and older.

Ryaltris Nasal Spray uses

• Treats symptoms of moderate to severe seasonal allergic rhinitis (hay fever) and related eye symptoms in adults, adolescents, and children 6 years of age and older
• Treats seasonal allergic rhinitis
• Relieves nasal congestion
• Relieves sneezing
• Reduces runny nose

Benefits of Ryaltris Nasal Spray

• Relief of nasal allergic symptoms observed within 15 minutes after use
• Reduces stuffy, runny, or itchy nose, sneezing, and eye redness, itching, and watering
• Best results achieved with regular use at consistent intervals
• Combines an antihistamine and corticosteroid in one spray
• Controls several nasal allergy symptoms
• Suitable for patients 6 years and older
• Provides twice-daily allergy treatment

How Ryaltris Nasal Spray works

RYALTRIS works by decreasing inflammation in the nose caused by seasonal allergies. One ingredient blocks histamine, a substance your body makes during an allergic reaction, while the other is a corticosteroid that reduces inflammation. Together they help reduce symptoms like a stuffy, runny, or itchy nose, sneezing, and itchy, watery, red eyes.

Ryaltris Nasal Spray dosage

For use in the nose only — do not spray into the eyes or mouth. Shake the bottle well for at least 20 seconds before each use. Prime the bottle before first use by releasing several sprays into the air until a fine mist appears, away from the face. Re-prime with a couple of sprays if the spray has not been used for 7 days or more (some sources say 14 days).

Gently blow your nose to clear your nostrils before using the spray. Tilt your head forward slightly, keep the bottle upright, and breathe in gently through the nose while spraying; breathe out through the mouth afterward. Avoid blowing your nose for about 15 minutes after use so the medicine has a chance to work. Do not tip your head back right after using, to keep the medicine from running into the throat.

Wipe the spray tip with a clean, dry tissue or cloth after each use and replace the cap securely until it clicks. If you miss a dose, take the next dose at its regular time — do not double up to make up for a missed dose. Adults and adolescents use it twice daily (morning and evening); children use a lower number of sprays, also twice daily. Do not try to unblock the spray tip with a pin or sharp object; soak the pump unit in warm water instead if it becomes clogged, then re-prime before using again.

Available forms and strengths

• Nasal spray (suspension)

Side effects of Ryaltris Nasal Spray

Common

• Altered or unpleasant sense of taste (dysgeusia)
• Headache
• Nosebleeds (epistaxis)
• Nasal discomfort, crusting, or sores in the nose
• Sleepiness or drowsiness
• Fatigue
• Cough
• Throat irritation
• Upper respiratory tract infection

Serious

• Urinary tract infection (pain or burning when urinating, frequent urination, blood in urine, pelvic pain, strong-smelling or cloudy urine)
• Nasal septal perforation (small holes in the wall between the nostrils; whistling sound when breathing)
• Fungal infection in the nose or throat (redness or white-colored patches in nose or mouth)
• Cataracts (glare, reduced vision)
• Glaucoma (increased eye pressure, eye pain)
• Infection (fever, aches or pains, chills, feeling tired)
• Decreased adrenal function (tiredness, weakness, nausea, vomiting)
• Serious allergic reaction (wheezing, rash, hives, swelling of face/mouth/tongue, breathing problems)

Warnings and precautions

• Do not use this medicine if you have an untreated fungal, bacterial, or tuberculosis infection of the respiratory tract, or a severe nasal infection such as candidiasis.
• This medicine can cause nose and throat problems including nosebleeds, sores in the nose, or a hole in the wall between the nostrils (nasal septal perforation).
• Because corticosteroids can slow wound healing, avoid use if you have recently had nasal surgery, nasal trauma, or nasal ulcers until healing is complete.
• This medicine can cause fungal infections (such as thrush/Candida) in the nose or throat. Tell your healthcare provider about any redness or white patches in the nose or mouth.
• This medicine can increase the risk of infections because it may weaken the immune system, and it may make chickenpox or measles more serious, especially in those who have not had these illnesses before.
• Eye problems such as blurred vision, cataracts, glaucoma, or central serous chorioretinopathy (CSCR) may occur. Tell your healthcare provider right away about any changes in vision.
• This medicine may slow growth in children using it. Children's growth should be checked regularly while using this medicine.
• Switching from an oral or injected steroid medicine to this nasal spray may cause withdrawal symptoms like joint pain, muscle pain, tiredness, or low mood, and may unmask other allergic conditions that were previously controlled.
• Certain medicines (such as some HIV medicines, antifungals like ketoconazole or itraconazole, and some antibiotics or antidepressants) can raise the levels of this medicine in the body and increase the risk of steroid-related side effects.
• RYALTRIS should only be used during pregnancy if the potential benefit to the mother justifies the potential risk to the unborn baby, especially during the first trimester. It is not known if RYALTRIS will harm an unborn baby.
• It is not known whether RYALTRIS passes into breast milk. It should be used by breastfeeding mothers only if the potential benefit to the mother outweighs the potential risk to the infant.
• No specific studies on RYALTRIS have been done in people with kidney problems, but based on the individual ingredients, no dose adjustment is thought to be needed.
• No specific studies on RYALTRIS have been done in people with liver problems, though levels of one ingredient (mometasone) may be higher in people with more severe liver impairment. Based on data for the individual ingredients, no dose adjustment is thought to be needed.
• Avoid drinking alcohol or taking other medicines that can cause drowsiness while using this medicine, since combining them can increase sleepiness and reduce alertness.
• This medicine may cause drowsiness or reduced alertness. Avoid driving or operating machinery until you know how this medicine affects you.

Storage

• Store at room temperature (15 to 30°C), or as specified between 20°C and 25°C with excursions permitted 15-30°C
• Protect from light
• Do not freeze or refrigerate
• Keep out of reach and sight of children
• Use within 2 months of first opening
• Store upright with the dust cap on
• Discard the bottle after the labeled number of sprays have been used, even if it does not feel empty, since the correct dose can no longer be assured
• Safely throw away medicine that is out of date or no longer needed

When to see a doctor

• Get immediate medical help if you have signs of a serious allergic reaction such as wheezing, rash, hives, swelling of the face, mouth, or tongue, or trouble breathing.
• Tell your healthcare provider right away if you notice redness or white patches in your nose or mouth, which could be a fungal infection.
• Tell your healthcare provider right away about any changes in your vision.
• Seek medical advice right away if you develop signs of infection such as fever, aches or pains, chills, or feeling tired, especially if you have been exposed to chickenpox or measles.
• Watch for symptoms of adrenal insufficiency, such as tiredness, weakness, nausea, vomiting, or low blood pressure, and contact your healthcare provider if these occur.
• If a child accidentally swallows this medicine, or if you use too much, contact a healthcare professional or go to the nearest hospital emergency room right away, even if there are no symptoms.

Alternatives

• Azelastine nasal spray
• Mometasone nasal spray
• Fluticasone nasal spray