Seebri Breezhaler Inhaler: Uses, Dosage, Side Effects, Precautions and Alternates

Quick overview

Seebri Breezhaler Inhaler contains glycopyrronium bromide, a long-acting muscarinic antagonist bronchodilator delivered as an inhaled powder. It is used for long-term, once-daily maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults, helping to relieve breathing symptoms such as shortness of breath and wheezing. It works by relaxing the muscles around the airways. It is not for treating sudden COPD attacks.

What is Seebri Breezhaler Inhaler

Seebri Breezhaler is an inhaled medicine containing glycopyrronium bromide, a type of bronchodilator. It is delivered as a powder in a capsule that you breathe in using a special inhaler device.

Seebri Breezhaler Inhaler uses

• Long-term, once-daily maintenance treatment to relieve breathing symptoms in adults with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema
• Treats chronic obstructive pulmonary disease (COPD)
• Provides maintenance bronchodilation
• Helps reduce shortness of breath
• Helps reduce wheezing
• Helps improve airflow

Benefits of Seebri Breezhaler Inhaler

• Improves lung function over 24 hours with once-daily use
• Reduces breathlessness and improves quality of life scores
• Reduces the use of rescue inhaler medication
• Lengthens the time before a COPD flare-up occurs

How Seebri Breezhaler Inhaler works

In COPD, the muscles around the airways tighten, making it hard to breathe. This medicine blocks the chemical signal (acetylcholine) that causes these muscles to tighten, which relaxes the airways and makes breathing easier.

Seebri Breezhaler Inhaler dosage

Inhale the contents of one capsule through the mouth once a day, every day at the same time. It can be used before or after food or drink. Do not swallow the capsules — they are for inhalation only. Use only with the Seebri Breezhaler inhaler provided in the pack; do not use with any other inhaler or capsules. Capsules must be kept in the blister and only removed immediately before use.

Continue using it every day, not just when you have symptoms, since it does not relieve sudden breathing problems. Keep a short-acting rescue inhaler with you for sudden symptoms, since this medicine does not treat acute attacks. If a dose is missed, take it as soon as possible, but do not take more than one dose in a day. Dispose of each inhaler after 30 days of use, even if some capsules remain.

Available forms and strengths

Inhalation powder hard capsules (50 mcg glycopyrronium per capsule), used with the Seebri Breezhaler inhaler device.

Side effects of Seebri Breezhaler Inhaler

Common

• Dry mouth
• Upset stomach, indigestion
• Pain in arms or legs
• Feeling of pressure or pain in the cheeks and forehead (sinus congestion)
• Nausea, vomiting, diarrhea and abdominal pain (gastroenteritis)
• Difficulty sleeping
• Symptoms of common cold (runny or stuffy nose, cough, sore throat, sneezing)
• Pain in muscles, bones or joints
• Cavities
• Rash
• Tiredness
• Weakness
• Throat irritation
• Nose bleeds
• Tingling or numbness
• Itching
• Voice alteration (hoarseness)
• Headache and urinary tract infection (more common in patients over 75 years)

Serious

• New or worsened irregular heartbeat
• Increased blood sugar: frequent urination, thirst, and hunger
• Difficulty or pain passing urine, urinating frequently, weak urine stream
• Signs of glaucoma: new or worsened eye pressure, eye pain, blurred vision, seeing halos around lights, red eyes
• Paradoxical bronchospasm: tightness of the chest, coughing, wheezing, or breathlessness right after inhaling
• Allergic reaction: rash, hives, swelling of the face, mouth, lips, throat and tongue, difficulty swallowing or breathing

Warnings and precautions

• This medicine is for long-term, once-daily maintenance treatment only. It should not be used to treat a sudden, severe COPD attack or to replace a fast-acting rescue inhaler.
• Use with caution if you have narrow-angle glaucoma or trouble urinating, as this medicine can worsen these conditions. Avoid getting the inhaled powder in your eyes, as this may trigger or worsen glaucoma.
• Serious allergic reactions have occurred with this medicine, including swelling of the face, lips, tongue, or throat, hives, or rash. If this happens, stop the medicine right away and get medical help.
• In rare cases, inhaling this medicine can unexpectedly cause sudden tightening of the airways (paradoxical bronchospasm), which can be life-threatening. If this happens, stop the medicine and seek alternative treatment right away.
• People with certain heart conditions were not studied with this medicine, so it should be used cautiously in these patients, and treatment may need to be stopped in some cases.
• Do not use this medicine more often than once a day or at a higher dose than prescribed, and do not use it together with other medicines of the same anticholinergic type, as this could lead to an overdose.
• There is no information on using this medicine during pregnancy. It should only be used if the expected benefit to the mother outweighs any possible risk to the baby.
• It is not known if this medicine passes into human breast milk. It was found in the milk of nursing rats. It should only be used while breastfeeding if the benefit to the mother outweighs any possible risk to the baby.
• People with severe kidney problems, including those on dialysis, should only use this medicine if the benefits outweigh the risks, and should be monitored closely by their doctor.
• No specific studies have been done in people with liver problems, but because the medicine is mainly removed from the body by the kidneys, no dose change is expected to be needed for liver problems.
• Dizziness or blurred vision from this medicine could affect your ability to drive or use machinery safely.

Storage

• Store at room temperature between 15 to 25°C
• Do not store above 25°C
• Store the capsules in the original blister in a dry place to protect from heat and moisture
• Do not remove capsules from the blister pack until immediately before use
• Do not use this medicine if you notice that the pack is damaged or shows signs of tampering
• Each inhaler should be disposed of after 30 days of use
• Keep out of sight and reach of children

When to see a doctor

• Get emergency medical care if your breathing problems worsen quickly, or if your rescue inhaler does not relieve your breathing problems.
• Tell your doctor immediately if you have chest tightness, coughing, wheezing, or breathlessness right after using this inhaler.
• Tell your doctor immediately and stop the medicine if you have difficulty breathing or swallowing, swelling of the tongue, lips or face, hives, itching, or skin rash — these may be signs of an allergic reaction.
• Tell your doctor right away if your COPD symptoms do not improve or get worse during treatment, and stop taking the medicine.
• Consult a doctor immediately if you have eye pain or discomfort, blurred vision, or see halos or colored images around lights with red eyes — these may be signs of an eye emergency called acute narrow-angle glaucoma.
• If you think you have inhaled too much of this medicine, contact your doctor or go to the nearest emergency unit immediately, even if you have no symptoms.

Alternatives

• Tiotropium
• Umeclidinium
• Aclidinium