Segluromet Tablet: Uses, Dosage, Side Effects, Precautions and Alternates

Quick overview

Segluromet Tablet combines ertugliflozin and metformin, two medicines from the SGLT2 inhibitor and biguanide classes, used together with diet and exercise to help control blood sugar in adults with type 2 diabetes. It works by helping the kidneys remove extra sugar through urine and by reducing the amount of sugar the liver makes while improving the body's response to insulin. It is taken twice a day with meals and is not intended for type 1 diabetes.

What is Segluromet Tablet

Segluromet is a tablet that contains two medicines combined together: ertugliflozin and metformin. It is used together with diet and exercise to help control blood sugar in adults with type 2 diabetes.

Segluromet Tablet uses

• Helps lower blood sugar levels in people with type 2 diabetes mellitus
• Used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes
• Can be used when blood sugar is not controlled on metformin alone, or when already controlled on ertugliflozin and metformin as separate tablets, or combined with sitagliptin when blood sugar is not controlled on metformin and sitagliptin
• Not used to treat type 1 diabetes

Benefits of Segluromet Tablet

• Helps lower blood sugar
• Improves glucose control
• Supports diabetes management
• May support modest weight reduction
• May help reduce blood pressure

How Segluromet Tablet works

Segluromet contains two medicines that work in different ways. Ertugliflozin helps your kidneys remove extra sugar from your body through your urine. Metformin works by lowering the amount of sugar that your liver makes and also helps your body's own insulin work better.

Segluromet Tablet dosage

Take it twice a day with meals. Taking it with food can help lower the chance of having an upset stomach. Follow your doctor's instructions about how to take it; your dose may be adjusted over time.

If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose - do not take two doses at once. Call your doctor if you are sick with vomiting or diarrhea, eating or drinking less than usual, or sweating more than usual.

Your blood sugar will need to be checked often, and you may need to test ketones in your urine. This medicine is only part of a complete treatment plan that may include diet, exercise, weight control, and regular blood sugar testing. Your doctor may have you take extra vitamin B12.

Available forms and strengths

• Oral tablets: 7.5 mg/1000 mg

Side effects of Segluromet Tablet

Common

• Yeast infection of the vagina or penis
• Diarrhea
• Nausea or vomiting
• Gas
• Stomach pain, upset stomach
• Feeling unusually weak or tired
• Headache
• Urinating more than usual

Serious

• Severe allergic reactions (breathing problems, swelling of face/lips/tongue/throat, hives)
• Diabetic ketoacidosis
• Lactic acidosis
• Dehydration leading to low blood pressure or kidney damage
• Kidney infections (pyelonephritis or urosepsis)
• Low blood sugar (hypoglycemia), especially when combined with insulin or other diabetes medicines
• Necrotizing fasciitis (a rare but serious infection of the genital or rectal area)
• Vitamin B12 deficiency leading to anemia
• Increased risk of lower limb amputation
• Acute kidney injury
• Hemolytic anemia
• Pancreatitis
• Peripheral neuropathy linked to vitamin B12 deficiency
• Encephalopathy
• Liver problems or hepatitis

Warnings and precautions

• Segluromet can cause a rare but serious buildup of lactic acid in the blood called lactic acidosis, which can be life-threatening and requires hospital treatment. Segluromet can cause diabetic ketoacidosis (DKA), a serious condition that can happen even with normal or only slightly high blood sugar levels. 
• Do not use Segluromet if you have type 1 diabetes or a history of diabetic ketoacidosis.
• Segluromet may increase the risk of lower leg or foot amputation, especially in people who have had a previous amputation, foot ulcers, poor circulation, or nerve damage in the legs. Segluromet can cause serious infections of the genital or rectal area that can worsen quickly. If you need an x-ray or CT scan using an injected dye, you may need to temporarily stop taking Segluromet.
• Segluromet should not be used during pregnancy because it may harm an unborn baby. Tell your doctor right away if you become pregnant.
• You should not breastfeed while taking Segluromet, since it is not known if it passes into breast milk and it could affect a nursing baby's kidney development.
• Segluromet should not be used if you have kidney disease or if your kidneys are not working well. Your doctor will test your kidney function before and during treatment.
• Segluromet should not be used if you have severe liver problems, since this can increase the risk of a serious condition called lactic acidosis.
• Avoid drinking alcohol, or drinking too much, while taking Segluromet, since alcohol can increase your risk of a dangerous buildup of lactic acid in the blood and can also affect your blood sugar.
• Segluromet may make you feel dizzy, weak, or lightheaded. Do not drive or use machines until you know how this medicine affects you.

Storage

• Store at room temperature, between 68 F and 77 F (20 C and 25 C)
• Can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods, such as when transporting it
• Store in a cool, dry place
• Protect from moisture
• Keep out of reach and sight of children

When to see a doctor

• Get emergency help right away if you have signs of a serious allergic reaction, such as hives, trouble breathing, or swelling of your face, lips, tongue, or throat.
• Seek medical help right away if you have symptoms of diabetic ketoacidosis, such as trouble breathing, nausea, vomiting, stomach pain, confusion, unusual tiredness, or a fruity smell on your breath - even if your blood sugar is normal.
• Get help right away if you notice signs of lactic acidosis, such as unusual muscle pain, trouble breathing, stomach pain, nausea with vomiting, irregular heartbeat, dizziness, or feeling very weak or tired.
• Seek medical help right away if you notice signs of a genital infection, such as burning, itching, odor, discharge, pain, tenderness, redness, or swelling in the genital or rectal area, along with fever or feeling unwell.
• Call your doctor right away if you notice new pain, tenderness, sores, ulcers, or infections on your legs or feet, as these could be signs that may lead to the need for amputation if untreated.
• Call your doctor right away if you have little or no urination, or other signs of a kidney problem.
• Contact your doctor right away if you have signs of a bladder or urinary tract infection, such as pain or burning when you urinate, fever, or pain in your back or pelvis.

Alternatives

• Glyxambi
• Xigduo XR
• Synjardy