Vibegron Tablet: Uses, Dosage, Side Effects, Precautions and Alternates

Quick overview

Vibegron Tablet, known generically as vibegron, is a prescription medicine belonging to the urinary antispasmodic class of beta-3 adrenergic agonists. It is sold under the brand name Gemtesa and is used to treat overactive bladder symptoms such as urgency, frequency, and leakage. It works by relaxing the bladder muscle so the bladder can hold more urine. It is taken as a tablet, usually once daily, exactly as prescribed by a doctor.

What is Vibegron Tablet

Vibegron is a prescription tablet used to treat overactive bladder. It belongs to a group of medicines called beta-3 adrenergic agonists, also described as urinary antispasmodics, and is sold under the brand name Gemtesa.

Vibegron Tablet uses

• Treats symptoms of overactive bladder, including urinary incontinence (leaking or wetting accidents), urgency, and frequent urination
• Used in men who are also taking medicine for benign prostatic hyperplasia (enlarged prostate) to help manage bladder symptoms

Benefits of Vibegron Tablet

• Helps treat overactive bladder symptoms
• Reduces sudden and urgent need to urinate
• Helps decrease frequent urination
• Can reduce urge incontinence (urine leakage)
• Helps the bladder store urine for longer by relaxing the bladder muscle

How Vibegron Tablet works

Vibegron relaxes the muscle of the bladder wall, which lets the bladder hold more urine and reduces sudden urges and leakage.

Vibegron Tablet dosage

Vibegron can be taken with or without food; if it upsets your stomach, take it with food. Take it at the same time every day. Swallow the tablet whole with a glass of water. If you cannot swallow the tablet whole, you may crush it and mix it with a small amount of applesauce, then swallow the mixture right away with a glass of water.

Keep taking it even if you feel well; do not stop without talking to your doctor, since it controls symptoms but does not cure the condition. Use and dosing in children must be determined by a doctor.

If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed one and go back to your regular schedule; do not double up doses.

Available forms and strengths

• Tablet

Side effects of Vibegron Tablet

Common

• Bladder pain
• Bloody or cloudy urine
• Blurred vision
• Difficult, burning, or painful urination
• Dizziness
• Frequent urge to urinate
• Headache
• Lower back or side pain
• Nervousness
• Pounding in the ears
• Slow or fast heartbeat
• Diarrhea
• Nausea
• Urinary tract infections
• Cold symptoms (stuffy nose, sneezing, sore throat)

Serious

• Trouble emptying the bladder or a weak urine stream (urinary retention)
• Decrease in urine volume or frequency of urination, or difficulty passing urine (dribbling)
• Painful, urgent, or frequent urination with fever
• Large, hive-like swelling of the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs (angioedema)
• Trouble breathing
• Skin rash, itching, or hives

Warnings and precautions

• This medicine can increase the risk of urinary retention (trouble passing urine or not fully emptying the bladder), especially if you already have bladder blockage or are taking certain other medicines.
• This medicine can cause a serious, potentially life-threatening allergic reaction called angioedema.
• Do not take other medicines, including over-the-counter drugs, herbal products, or vitamins, without discussing them with your doctor first.
• Use with caution if you have bladder blockage, as this medicine may make it harder to urinate.
• Tell your doctor if you are pregnant, plan to become pregnant, or become pregnant while taking this medicine.
• There isn't enough research to know if this medicine is safe during breastfeeding, so your doctor will weigh the benefits against possible risks before you take it while breastfeeding.
• This medicine is not recommended for people with end-stage kidney disease.
• This medicine is not recommended for people with severe liver disease.
• You may need to limit alcohol, since it may make overactive bladder symptoms worse.

Storage

• Store at 20–25°C (68–77°F) at controlled room temperature
• Keep in a cool, dry place away from excessive heat and humidity
• Protect tablets from moisture and direct sunlight
• Keep tablets in the original, tightly closed container until use
• Avoid storing in bathrooms or other hot and humid areas
• Keep out of reach and sight of children and pets

When to see a doctor

• Get medical help right away if you have a decrease in how much or how often you urinate, or trouble or dribbling when passing urine
• Get medical help right away if you notice large, hive-like swelling of the face, eyelids, lips, tongue, or throat, or trouble breathing
• Call your doctor immediately or get emergency care if you have difficulty emptying your bladder, a weak urine stream, fever with painful or frequent urination, swelling of the eyes, face, tongue, lips, or throat, or a rash, itching, or hives
• If you think you have taken too much of this medicine, contact a poison control center or go to an emergency room right away

Alternatives

• Fesoterodine
• Tolterodine
• Solifenacin
• Mirabegron